Highlight文献
| Highlight文献介绍页面，请详细此链接：CERO全自动细胞培养仪2024年重要文献总结 | Biokingdom | ||||||
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| 序号 | 文献英文标题 | 文献标题中文翻译 | 文献培养的细胞 | CERO 3D培养的内容 | 培养方法 | 结果 |
| 1 | Generation of a Syngeneic Heterozygous ACVRL1(wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis | 异源性ACVRL1(wt/mut)敲除iPS细胞系用于体外研究HHT2相关的血管生成 | iPSC衍生内皮细胞 | CERO 3D用于iPSC培养，通过CRISPR/Cas9敲除ACVRL1基因，生成血管生成障碍体外模型 | 将iPSC悬浮在CERO 3D培养器中，进行基因编辑后诱导分化为内皮细胞 | 成功建立了带有ACVRL1基因缺陷的iPSC细胞系，能够模拟HHT2疾病的血管生成障碍特征 |
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| 2 | Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions | 使用台式生物反应器在全定义条件下标准化生成人类iPSC衍生的造血类器官和巨噬细胞 | iPSC衍生巨噬细胞 | CERO 3D用于连续生成巨噬细胞，支持免疫模型构建和药物筛选 | 采用全定义化学成分培养基，悬浮培养iPSC以生成造血类器官，再分化为巨噬细胞 | 生成了功能稳定且一致的巨噬细胞模型，用于药物的免疫调节测试 |
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| 3 | Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia | 大规模生成功能性人类iPSC衍生的CAR巨噬细胞，有效清除CD19阳性白血病 | CAR修饰巨噬细胞 | CERO 3D用于大规模生成CAR-iMacs，研究其抗白血病的作用 | 将iPSC悬浮在CERO 3D系统中，分化生成具有CAR修饰的巨噬细胞 | 生成的CAR-iMacs表现出抗原特异性增强的吞噬能力和抗肿瘤反应 |
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| 4 | Generation of a Syngeneic Heterozygous ACVRL1(wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis | 异源性ACVRL1(wt/mut)敲除iPS细胞系用于体外研究HHT2相关的血管生成 | iPSC衍生内皮细胞 | CERO 3D用于iPSC培养，通过CRISPR/Cas9敲除ACVRL1基因，生成血管生成障碍体外模型 | 将iPSC悬浮在CERO 3D培养器中，进行基因编辑后诱导分化为内皮细胞 | 成功建立了带有ACVRL1基因缺陷的iPSC细胞系，能够模拟HHT2疾病的血管生成障碍特征 |
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| 5 | Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways | 溶血磷脂酸通过诱导自噬抑制高等级浆液性卵巢癌细胞凋亡并促进细胞周期进程 | 高等级浆液性卵巢癌细胞（A2780, OVCAR5） | CERO 3D用于卵巢癌细胞悬浮培养，研究LPA在细胞凋亡和自噬中的作用 | 在CERO 3D系统中悬浮培养癌细胞，并暴露于溶血磷脂酸 | 发现LPA抑制癌细胞凋亡，激活自噬并促进细胞周期进程，提供潜在靶点 |
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| 6 | Application-Oriented Bulk Cryopreservation of Human iPSCs in Cryo Bags Followed by Direct Inoculation in Scalable Suspension Bioreactors for Expansion and Neural Differentiation | 以应用为导向的大规模冷冻保存人iPSCs，随后直接接种至可扩展的悬浮生物反应器中进行扩展和神经分化 | iPSC衍生神经细胞 | CERO 3D用于批量冷冻保存和扩展iPSCs并进行神经分化 | iPSCs冷冻保存后直接复苏至CERO 3D中进行悬浮培养和神经分化 | 实现iPSC的批量神经分化，适合神经疾病模型研究 |
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| 7 | Reenacting Neuroectodermal Exposure of Hematopoietic Progenitors Enables Scalable Production of Cryopreservable iPSC‑Derived Human Microglia | 重现造血前体细胞的神经外胚层暴露，支持可冷冻保存的人类iPSC衍生小胶质细胞的大规模生产 | iPSC衍生小胶质细胞 | CERO 3D用于大规模生成小胶质细胞，研究其神经免疫反应 | iPSCs在CERO 3D中生成EBs，通过分化生成小胶质细胞 | 生成的功能性小胶质细胞适用于神经共培养模型 |
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| 8 | Scalable expansion of iPSC and their derivatives across multiple lineages | 多谱系iPSC及其衍生细胞的规模化扩展 | iPSC衍生的心脏、神经和肝脏细胞 | CERO 3D用于iPSC的悬浮培养和多谱系分化，支持毒理学研究 | iPSCs悬浮在CERO 3D中，通过分化生成多谱系细胞 | 生成多谱系iPSC衍生细胞，适用于药物毒性测试和筛选 |
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| 9 | Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies | 人iPSC衍生的肝细胞在2D和3D悬浮培养中的冷冻保存和体外毒性研究 | iPSC衍生肝细胞 | CERO 3D用于3D悬浮培养和肝类器官的冷冻保存，用于毒性研究 | iPSCs在CERO 3D中培养成肝类器官，冷冻保存后用于毒性测试 | 提供高质量肝类器官模型，优化毒性测试流程 |
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| 10 | Microfluidic 3D intestine tumor spheroid model for efficient in vitro investigation of nanoparticular formulations | 微流控三维肠道肿瘤球体模型用于高效体外研究纳米颗粒制剂 | 人结肠癌细胞（HT29-MTX-E12） | CERO 3D用于生成三维肿瘤球体模型，研究纳米颗粒在药物传递中的应用 | 结肠癌细胞在CERO 3D中培养成三维球体，并用于纳米颗粒研究 | 成功构建3D肿瘤模型，为纳米药物传递测试提供平台 |
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部分重点文献
| 文献中文名 | 文献英文名 | 发表时间 | 文献中提到的细胞种类 |
|---|---|---|---|
| 三维细胞培养：药物发现中的缺失环节 | Three-dimensional cell culture: the missing link in drug discovery | 2012 | |
| 特异性细胞类型的人工细胞外基质水凝胶的微流体合成 | Microfluidic synthesis of cell-type-specific artificial extracellular matrix hydrogels | 2013 | |
| 纳米颗粒长期效应评估 | Assessment of long-term effects of nanoparticles in a microcarrier cell culture system | 2013 | |
| 瑞香素诱导HeLa细胞凋亡：可能的线粒体依赖途径 | Daphnoretin-induced apoptosis in HeLa cells: a possible mitochondria-dependent pathway | 2014 | |
| 从海洋真菌中筛选抗癌化合物的表型筛选方法 | A phenotypic screening approach to identify anticancer compounds derived from marine fungi | 2014 | |
| 使用3D培养维持人脂肪来源干细胞的分化能力 | Maintenance of human adipose derived stem cell (hASC) differentiation capabilities using a 3D culture | 2014 | |
| 一种适用于三维细胞培养的新型微重力模拟器 | A Novel Microgravity Simulator Applicable for Three-Dimensional Cell Culturing | 2014 | |
| 在超声场中利用模态和谐波分析表征MCF7和MCF10A细胞的动态行为 | Characterization of Dynamic Behaviour of MCF7 and MCF10A Cells in Ultrasonic Field Using Modal and Harmonic Analyses | 2015 | |
| 人类多能干细胞动态扩展的可重现且多用途系统 | A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension | 2015 | |
| 牙髓干细胞来源外泌体保护人多巴胺能神经元免受6-羟多巴胺诱导的凋亡 | Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis | 2015 | |
| 人类间充质干/基质细胞治疗用途的生物工艺：当前技术和挑战 | Bioprocessing of human mesenchymal stem/stromal cells for therapeutic use: Current technologies and challenges | 2016 | |
| 优化人类诱导多能干细胞在搅拌悬浮培养中的扩展 | Optimizing Human Induced Pluripotent Stem Cell Expansion in Stirred-Suspension Culture | 2017 | |
| 生物反应器在干细胞培养中的应用 | Application of Bioreactor in Stem Cell Culture | 2017 | |
| 从海藻提取的藻酸盐用于人类干细胞培养的生物活性表面 | Bioactive surfaces from seaweed-derived alginates for the cultivation of human stem cells | 2017 | |
| 微载体培养增强了人类牙周膜基质细胞的成骨潜能 | Microcarrier culture enhances osteogenic potential of human periodontal ligament stromal cells | 2017 | |
| 完整工作流程用于诱导多能干细胞衍生心球的分化和解离 | A complete workflow for the differentiation and the dissociation of hiPSC-derived cardiospheres | 2018 | |
| 单细胞质谱揭示非小细胞肺癌细胞的复杂性 | Single Cell Mass Cytometry of Non-Small Cell Lung Cancer Cells Reveals Complexity of In Vivo and Three-Dimensional Models over the Petri-Dish | 2019 | |
| 细胞外囊泡抑制人类牙周膜干细胞中基础和脂多糖诱导的NFκB活性 | Extracellular Vesicles Suppress Basal and Lipopolysaccharide-Induced NFκB Activity in Human Periodontal Ligament Stem Cells | 2019 | |
| 3D动态培养系统中的MSCs在明胶微球上的软骨形成 | 3D Culture of MSCs on a Gelatin Microsphere in a Dynamic Culture System Enhances Chondrogenesis | 2020 | |
| 脊髓损伤细胞疗法：设计商业化制造设施 | Cell Therapy for Spinal Cord Injuries: Design of a Commercial Manufacturing Facility | 2020 | |
| 微流控3D肠道肿瘤球体模型用于高效体外研究纳米颗粒制剂 | Microfluidic 3D intestine tumor spheroid model for efficient in vitro investigation of nanoparticular formulations | 2021 | |
| 用于识别纳米颗粒长期效应的体外测试 | IN-VITRO TESTING FOR IDENTIFICATION OF LONG-TERM EFFECTS OF NANOPARTICLES | 2014 | |
| 具有定制物理化学特性的细胞诱导微胶 | Cell-Instructive Microgels with Tailor-Made Physicochemical Properties | 2015 | |
| 基于HET-CAM的血管化肠道肿瘤模型作为纳米配方光敏剂筛选平台 | A HET-CAM based vascularized intestine tumor model as a screening platform for nano-formulated photosensitizers | 2022 | |
| 有效生物工艺下游工艺开发策略：趋势、进展及组合方法 | Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches | 2017 | |
| 人类多能干细胞来源的肾近端小管上皮细胞的功能分化及可扩展生产 | Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture system | 2022 | |
| 中型生物反应器中从原代猪细胞制备球状体并保持其肌源潜能 | Preparation of Spheroids from Primary Pig Cells in a Mid-Scale Bioreactor Retaining Their Myogenic Potential | 2022 | |
| 2D 和 3D 悬浮培养中人类 iPSC 来源的肝细胞用于冷冻保存及体外毒性研究 | Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies | 2022 | |
| 多系人类iPSC及其衍生物的可扩展扩展 | Scalable expansion of iPSC and their derivatives across multiple lineage | 2022 | |
| 通过复现造血祖细胞的神经外胚层暴露来实现可扩展的人类iPSC来源小胶质细胞生产 | Reenacting neuroectodermal exposure of hematopoietic progenitors enables scalable production of cryopreservable iPSC-derived human microglia | 2022 | |
| 从发育期中跨越微观到纳米尺度成像三维脑类器官架构 | Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development | 2022 | |
| 溶血磷脂酸通过EGFR-PI3K/Aurora-AThr288-geminin双信号通路抑制高等级浆液性卵巢癌细胞的凋亡并促进细胞周期进展 | Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways | 2022 | |
| 大批量人类iPSC的应用导向性批量冷冻保存 | Application-Oriented Bulk Cryopreservation of Human iPSCs in Cryo Bags Followed by Direct Inoculation in Scalable Suspension Bioreactors for Expansion and Neural Differentiation | 2023 | |
| 动态生物反应器中的肺泡上皮样细胞分化：高通量生成肺细胞类型的3D方法 | Alveolar epithelial-like cell differentiation in a dynamic bioreactor: a promising 3D-approach for the high-throughput generation of lung cell types from human induced pluripotent stem cells | 2023 | |
| 人类iPSC来源的CAR巨噬细胞的规模化生成 | Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia | 2023 | |
| 人PBMCs在细胞模型上的固定对阿尔茨海默症中Aβ42聚集体依赖的促炎状态的影响 | The effect of human PBMCs immobilization on their Аβ42 aggregates-dependent proinflammatory state on a cellular model of Alzheimer’s disease | 2024 |